For Further Information Please Contact

Head, Bio-Materials Laboratory
CLRI, Adyar, Chennai 600 020.
Telephone.:+ 91 044 24420709
Fax: 91 44 24911589 
Email : mkgowthaman@clri.res.in

Publications & Patents

Technology Transferred
  1. Design and delivery of silver sulfadiazine from alginate microspheres - impregnated collagen scaffold. Journal of Biomedical Materials Research Part B Applied Biomaterials , In press
  2. Isolation, purification and characterization of collagenase from hepatopancreas of the land snail Achatina fulica . Comparative Biochemistry and Physiology part B. Published online (Science Direct), July 2005
  3. Ultrastructural differntiation of abnormal scars. Annals of Burn and Fire Disaster 28(2), 83-88. 2005.
  4. Cytotoxicity studies of chromium (III) complexes on human dermal fibroblasts. Free Radical Biology and Medicine 38, 58-69. 2004.
  5. Cellosia argentea Linn. Leaf extract improves wound healing in a rat burn wound model. Wound Repair and Regeneration 12: 618-625. 2004.
  6. Comparative physico-chemical and in vitro properties of fibrillated collagen scaffolds from different sources. Journal of Biomaterials Applications 18: 247-264. 2004.
  7. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. British Journal of Pharmacology 139: 1342-1350 . 2003.
  8. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. Journal of Ethnopharmacology, 88(2-3), 235-239. 2003.
  9. Biocompatible collagen scaffolds from a human amniotic membrane: physicochemical and in vitro culture characteristics. Journal of Biomaterials Science. Polymer Edition, Volume 14, No. 7, 689-706. 2003.
  10. Application of frog (Rana tigerina Daudin) skin collagen as a novel substrate in cell culture. J.Biomed.Mater.Res. 61: (2): 197-202. 2002.
  11. The involvement of free radicals in burn injury: A review. Burns: 27,309-317. 2001.
  12. Dermal-epidermal communication in wound healing. Wounds 13(5) pp. 183-189. 2001.
  13. Effect of Trypsin-chymotrypsin preparation on the modulation of cytokines levels in the burn patients. Burns, 27, 34-40. 2001.
  14. Skin substitutes – a review. Burns, 27, 534-544. 2001.
  15. Studies on Rana tigerina collagen. Comparative Biochemistry and Physiology Part B 128, 81-90. 2001.
  16. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. British Journal of Pharmacology Vol.131, pp.169-172. 2000.
  17. Collagen based dressings – A review. Burns Vol. 26, pp 54-62. 2000.
  18. Development of autologous human epidermal/dermal composites based on sterilized human allodermis suitable for clinical use. British Journal of Dermatology Vol. 141, pp 811-823. 1999.
  19. Physicochemical properties of extracellular matrix proteins in post-burn human granulation tissue. Comparative Biochemistry and Physiology. Part B Vol. 124 pp 241-249. 1999.
  20. Cellular proliferation on desamidated collagen matrices. Comparative Biochemistry and Physiology. Part C Vol. 124 pp. 131-139. 1999.
  21. The effect of anti-allergic agent avil on abnormal scar fibroblast. Burns Vol. 25 pp 223-228. 1999.
  22. Frog skin as a wound cover. Nature News India . April pp-7. 1999.
  23. Growth potential of Rana tigerina skin lipids in cell culture. In Vitro Cell Dev. Biol-Animal Vol. 34, pp 561-567. 1998.
  24. Ultrastructural studies of keloids. Biomedical letters Vol. 58, pp 41-50. 1998.
  25. Serum enzymatic changes modulated using Trypsin: Chymotrypsin preparation during burn wounds in humans. Burns Vol. 23(7&8) pp 560-564. 1997.
  26. Expression of Keratin in Postburn Scars and Keloids. Annals of Mediterrenean Burns Club-Burns and Fire Disasters, Vol.III. pp 220-223. 1995.
  27. Efficiency of controlled topical delivery of silver sulphadiazine in infected burn wounds. Journal of Biomedical Materials Research part A. In press
  28. Functionally modified gelatin microspheres impregnated collagen scaffold as novel wound dressing to attenuate the proteases and bacterial growth. European Journal of Pharmaceutical Sciences. 2009, 36, 235-245
  29. Isolation and characterization of biologically metal doped protein as semiconducting biopolymer. Materials chemistry and physics, 111(2-3), 2008, 517-523
  30. Preparation and characterization of chitosan microspheres for doxycycline delivery. Carbohydrate Polymers. (2008) 73(2), 201-211
  31. Electrical conductivity as a tool for identification of metal contaminated fish protein. Journal of Food Engineering. (2008), 83(3), 405-410
  32. Cytotoxic effect of achantininH (Lectin) from Achatina fulica against a human mammary carcinoma cell line (MCF 7 In Vitro Cellular & Developmental Biology-Animal, 2007, 43, 306-314
  33. Etiology and Management of ear lobule keloid in south India Plastic and Reconstructive Surgery. Jan 2007. pp 435-437.
  34. Gelatin microspheres crosslinked with EDC as a drug delivery system for doxycycline: development and characterization. Journal of Microencapsulation, 2007, 24(7), 659-671
  35. Radio-protective effect of 2- Deoxy- D- Glucose in cervical cancer patients lymphocytes exposed in-vitro as estimated by the Comet assay. Int J Hum Genetics ; 6(4) , 2006.pp 303-308.
  36. Bleomycin- Induced oxidative stress and lung injury in rats: Inhibition by curcumin. Letters in Drug Design and Discovery No: 9 Dec 2006 pp 714-722.
  37. Low Molecular Weight Heparin-Induced Pharmacological Modulation of Burn Wound Healing. Annals of Burns and Fire Disasters, vol. XIX no.3 September 2006
  38. Design and delivery of silver sulfadiazine from alginate microspheres - impregnated collagen scaffold. Journal of Biomedical Materials Research Part B Applied Biomaterials, 77B,2, 2006,378-388.

 

Publications

  1. Keloids and hypertrophic scars: a review .Indian J Plast Surg July-dec 2005 Vol 38 Iss. No 2.pp 175-179
  2. Babitha S and Purna Sai Korrapati. Biosynthesis of titanium dioxide nanoparticles using a probiotic from coal fly ash effluent. Materials Research Bulletin,2013,48,4738-4742.
  3. Narendra Reddy Chereddy, Purna Sai Korrapati, Sathiah Thennarasu and Asit Baran Mandal .Tuning  Copper (II) ion selectivity: the role of basicity, size of the chelating ring and orientation of coordinating atoms. Dalton Trans., 2013, 42, 12873-12877.
  4. Chereddy NR, Janakipriya S, Korrapati PS, Thennarasu S, Mandal AB. 2013.Solvent-assisted selective detection of sub-micromolar levels of Cu(2+) ions in aqueous samples and live-cells. Analyst. 138, 1130.
  5. Karthikeyan. K, Soma. G, Rama. R, Purna Sai K. 2012. Electrospun Zein/Eudragit  Nanofibers based Dual Drug Delivery System for the Simultaneous Delivery of Aceclofenac and Pantoprazole. International Journal of Pharmaceutics,438:117-122.
  6. K. Karthikeyan, Rachita Lakra, Rama Rajaram and Purna Sai Korrapati 2012.Development and Characterization of Zein based Micro Carrier system for Sustained Delivery of Aceclofenac Sodium. AAPS PharmSciTech, 13 :( 1):143-149.
  7. Nirupa Shyam Mogili, Venkat Raghavan Krishnaswamy, Meenakshi Jayaraman, Rama Rajaram, Alamelu Venkatraman, Korrapati Purna Sai . 2012. Altered angiogenic balance in keloids: a key to therapeutic intervention. Translational Research. 159:182-189.
  8. Venkat Raghavan K, Mary Babu, Rama Rajaram, Korrapati Purna Sai 2010. Efficacy of frog skin lipids in wound healing. Lipids in Health and Disease, 9:74.
  9. Gladstone Christopher Jayakumar, Swarna Vinodh Kanth, Purnasai Korrapati,  Bangaru  Chandrasekaran   Jonnalagadda Raghava Rao, Balachandran Unni Nair. 2012. Scleraldehyde as a stabilizing agent for collagen scaffold preparation. Carbohydrate polymers, 87:1482-1489.
  10. C.H. Narendra Reddy, K. Suman, K. Purna Sai, S.  Thennarasu and A.B. Mandal 2012. Design and synthesis of rhodamine based chemosensors  for  the detection  of Fe3+ions. Dyes & Pigments 95; 606-613.

Patents
  1. A process for the preparation of a novel collagen scaffold capable of delivering antibacterial agent loaded microspheres in a controlled manner. Indian Patent filed 314 Del 2004.
  2. A process for the preparation of plant based-reconstituted collagen substratum. Indian Patent, No. 84 DEL2002
  3. A process for preparation of reconstituted collagen substratum. Indian Patent, No. NF 239/2000.

For Further Information Please Contact

Head, Bio-Materials Laboratory
CLRI, Adyar, Chennai 600 020.
Telephone.:+ 91 044 24420709
Fax: 91 44 24911589 
Email : mkgowthaman@clri.res.in