CSIR-Central Leather Research Institute
Dr.T. S. Uma
Senior Scientist
Academic Qualifications
    Ph.D (University of Madras)
Contact Details
Dr.T. S. Uma
Senior Scientist

Biological Material Laboratory
CSIR-Central Leather Research Institute
Adyar, Chennai – 600 020
e-mail: tsuma@clri.res.in,
Phone:91 44 22420709


Qualification
 

Ph.D , University of Madras (1999)

Area of Interest:
 
  • Biomaterial development
  • Electrospinning
  • Biosensors
  • Nanoparticles
  • Drug delivery
  • Anticancer activity
  • Tannery byproducts
R & D Activities
 
  • Electrospun layered double hydroxide nano-particles for drug delivery studies
  • Development of nanobased assays for the early detection of breast cancer
  • Development of inorganic nano based tools for dosimetric studies
  • Engineered nanoparticles for anticancer studies
  • Extraction of keratin from bovine source
  • Stress induced microbial siderophores as MMP inhibitors
  • Extraction of collagen from marine and bovine source
  • Preparation of value added products from tannery byproducts
  • Development of nanoparticle based biosensors
  • Studies on antiviral inhibitors against virus
Technology Transferred
  1. Inbasekaran, T.S.Uma, B.N.Das, A.B.Mandal, T.P.Sastry. Blended leather fabrics for the preparation thereof. Application No: 2416DEL2014.
Membership in the Professional Body
  • Member of Annual wound healing society of India
  • Member  of society for biomaterial and artificial organs
DST Funded projects
  • Engineered nanomaterials for drug delivery
  • Nanobased tools for medical applications
  • Collagen extraction from marine source
  • Microbial Siderophores for MMP inhibition
ICMR funded project
  • Electrospinning of polymeric biomaterials for burn wounds
Book Chapters
  1. Naveen Nagiah, Giriprasath Ramanathan, Tiruchirapalli Sivagnanam Uma, Tirupattur Srinivasan Natarajan
    Synthesis of blended fibers of poly (3-hydroxybutyric acid) and poly (propylene carbonate) scaffolds for tissue engineering, Nanobiomaterials, Bloomsbury Publishers 2012((ISBN 978-93-82563-37-2).
  2. Naveen Nagiah, Sivakumar Singaravelu, Tiruchirapalli Sivagnanam Uma,Tirupattur Srinivasan Natarajan.
    Development of electrospun poly (propylene carbonate) and polycaprolactone scaffolds for tissue engineering, Nanobiomaterials, Bloomsbury Publishers 2012(ISBN 978-93-82563-37-2)
List of Publications
  1. Giriprasath Ramanathan, Sivakumar Singaravelu, Raja M.D, Uma Tiruchirapalli Sivagnanam.
    Synthesis of highly interconnected 3D scaffold from Arothron stellatus skin collagen for tissue engineering application. Micron 78 (2015) 28–32.
  2. Sivakumar Singaravelu, Giriprasath Ramanathan, M.D. Raja, Sagar Barge, Uma Tirichurapalli Sivagnanam:
    Preparation and characterization of keratin-based biosheet from bovine horn waste as wound dressing material. Materials Letters 08/2015; 152. DOI:10.1016/j.matlet.2015.03.088.
  3. Subramani Kandhasamy, Giriprasath Ramanathan, Kamalraja Jayabal, Ravichandran Balaji, Mathivanan Narayanasamy, Uma Tirichurapalli Sivagnanam, Perumal Paramasivan Thirumalai:
    Synthesis, characterization and biological evaluation of chromen and pyrano chromen-5-one derivatives impregnated into a novel collagen based scaffold for tissue engineering application. RSC Advances 06/2015; 5(68). DOI:10.1039/C5RA07133J
  4. Naveen Nagiah, Giriprasath Ramanathan, Liji Sobhana, Uma Tirichurapalli Sivagnanam, Natarajan Tirupattur Srinivasan:
    Poly (vinyl alcohol) Microspheres Sandwiched Poly (3-hydroxybutyric acid) Electrospun Fibrous Scaffold for Tissue Engineering and Drug Delivery. International Journal of Polymeric Materials 07/2014; 63(11). DOI:10.1080/00914037.2013.854230
  5. Raja Modhugoor Devendiran, Senthil Kumar Chinnaiyan, Ranjeet Kumar Mohanty, Giriprasath Ramanathan, Sivakumar Singaravelu, S. S. Liji Sobhana, Uma Tirichurapalli Sivagnanam:
    Sunlight Mediated Biosynthesis and Characterisation of Gold Nanoparticles Using Pisonia grandis Leaf Extract for Biomedical Applications. Journal of Biomaterials and Tissue Engineering 06/2014; 4(6). DOI:10.1166/jbt.2014.1196
  6. N. Adhirajan, R. Thanavel, N. Naveen, T. S. Uma, Mary Babu:
    Functionally modified gelatin microspheres as a growth factor’s delivery system: development and characterization. Polymer Bulletin 03/2014; 71(4). DOI:10.1007/s00289-014-1108-3
  7. Dhivya Bhoopathy, Bhaskaran Ravi Latha, T S Uma, C Sreekumar, V Leela:
    A novel approach to control brown dog tick, Rhipicephalus sanguineus using sustained release poly-E -caprolactone-pheromone microspheres. Acta Parasitologica 03/2014; 59(1):153-7. DOI:10.2478/s11686-014-0224-4
  8. Giriprasath Ramanathan, Sivakumar Singaravelu, M. D. Raja, S. S. Liji Sobhana, Uma Tirichurapalli Sivagnanam:
    Extraction and Characterization of Collagen from the Skin of Arothron stellatus Fish—A Novel Source of Collagen for Tissue Engineering. Journal of Biomaterials and Tissue Engineering 03/2014; 4(3). DOI:10.1166/jbt.2014.1157
  9. Uma Maheshwari Subramanian, Samuel Vasanth Kumar, Naveen Nagiah, Uma Tiruchirapally Sivagnanam:
    Fabrication of Polyvinyl Alcohol-Polyvinylpyrrolidone Blend Scaffolds via Electrospinning for Tissue Engineering Applications. International Journal of Polymeric Materials 02/2014; 63(9). DOI:10.1080/00914037.2013.854216
  10. Rethinam Senthil, Thiagarajan Hemalatha, Baskar Santhosh Kumar, Tiruchirapalli Sivagnanam Uma, Bhabendra Nath Das, Thotapalli Parvathaleswara Sastry:
    Recycling of finished leather wastes: a novel approach. Clean Technologies and Environmental Policy 01/2014; 17(1):187-197. DOI:10.1007/s10098-014-0776-x
  11. Naveen Nagiah, Giriprasath Ramanathan, Tiruchirapalli Sivagnanam Uma, Lakshmi Madhavi, Anitha R, Tirupattur Srinivasan Natarajan:
    Synthesis of Blended Fibers of Poly(3-hydroxybutyric acid) and Poly(propylene carbonate) Scaffolds for Tissue Engineering. Advances in Polymer Technology 12/2013; 32(4). DOI:10.1002/adv.21370
  12. Naveen Nagiah, Giriprasath Ramanathan, Liji Shobana, Sivakumar Singaravelu, Tiruchirapalli Sivagnanam Uma, Tirupattur Srinivasan Natarajan:
    Preparation and Characterization of Electrospun Poly(3-Hydroxybutyric acid)–Poly( N -vinylpyrrolidone) and Poly(caprolactone)–Poly( N -vinylpyrrolidone) Fibers as Potential Scaffolds for Skin Regeneration. Journal of Biomaterials and Tissue Engineering 12/2013; 3(6):624-629. DOI:10.1166/jbt.2013.1130
  13. Subramanian Uma Maheshwari, Samuel Vasanth Kumar, Naveen Nagiah, Tiruchirapalli Sivagnanam Uma:
    Electrospinning of polyvinylalcohol–polycaprolactone composite scaffolds for tissue engineering applications. Polymer Bulletin 11/2013; 70(11). DOI:10.1007/s00289-013-1002-4
  14. Naveen Nagiah, Lakshmi Madhavi, R Anitha, C Anandan, Natarajan Tirupattur Srinivasan, Uma Tirichurapalli Sivagnanam:
    Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration. 10/2013; 33(7):4444-52. DOI:10.1016/j.msec.2013.06.042
  15. Naveen Nagiah, Lakshmi Madhavi, R. Anitha, Natarajan Tirupattur Srinivasan, Uma Tirichurapalli Sivagnanam:
    Electrospinning of poly (3-hydroxybutyric acid) and gelatin blended thin films: Fabrication, characterization, and application in skin regeneration. Polymer Bulletin 08/2013; 70(8). DOI:10.1007/s00289-013-0956-6
  16. Naveen Nagiah, Uma Tiruchirapalli Sivagnanam, Ranganathan Mohan, Natarajan Tirupattur Srinivasan, Praveen Kumar Sehgal:
    Development and Characterization of Electropsun Poly(propylene carbonate) Ultrathin Fibers as Tissue Engineering Scaffolds. Advanced Engineering Materials 04/2012; 14(4). DOI:10.1002/adem.201180041
  17. N. Naveen, R. Kumar, S. Balaji, T. S. Uma, T. S. Natrajan, P. K. Sehgal:
    Synthesis of Nonwoven Nanofibers by Electrospinning - A Promising Biomaterial for Tissue Engineering and Drug Delivery. Advanced Engineering Materials 08/2010; 12(8):B380–B387. DOI:10.1002/adem.200980067
  18. Ramadhar Kumar, S Balaji, R Sripriya, N Nithya, T S Uma, P K Sehgal:
    In Vitro Evaluation of Antioxidants of Fruit Extract of Momordica charantia L. on Fibroblasts and Keratinocytes. Journal of Agricultural and Food Chemistry 02/2010; 58(3):1518-22. DOI:10.1021/jf9025986
  19. Ramadhar Kumar, S Balaji, T S Uma, P K Sehgal:
    Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPARγ and PI3K. Journal of ethnopharmacology 10/2009; 126(3):533-7. DOI:10.1016/j.jep.2009.08.048
  20. N Shanmugasundaram, T S Uma, T S Ramyaa Lakshmi, Mary Babu:
    Efficiency of controlled topical delivery of silver sulfadiazine in infected burn wounds. Journal of Biomedical Materials Research Part A 05/2009; 89(2):472-82. DOI:10.1002/jbm.a.31997
  21. Ramadhar Kumar, S Balaji, T S Uma, A B Mandal, P K Sehgal:
    Optimization of influential parameters for extracellular keratinase production by Bacillus subtilis (MTCC9102) in solid state fermentation using Horn meal-a biowaste management.. Applied biochemistry and biotechnology 01/2009; 160(1):30-9. DOI:10.1007/s12010-008-8452-4
  22. N Shanmugasundaram, J Sundaraseelan, S Uma, D Selvaraj, Mary Babu:
    Design and delivery of silver sulfadiazine from alginate microspheres-impregnated collagen scaffold. Journal of Biomedical Materials Research Part B Applied Biomaterials 05/2006; 77(2):378-88. DOI:10.1002/jbm.b.30405
List of Patents
  1. R.Senthil, S.Inbasekaran, T.S.Uma,B.N.Das, A.B.Mandal, T.P.Sastry. Blended leather fabrics for the preparation thereof. Application No: 2416DEL2014.
  2. Development of Keratin film and spongy scaffold and a process for the preparation thereof. S.Balaji, Ramadhar Kumar, Sripriya, T.S.Uma, P.K.Sehgal. IPR NO.: 0065NF2010
  3. Development of multilayered collagen scaffold for phase – wise and sustained /controlled delivery of the therapeutic. Ramadhar Kumar, Sripriya, S.Balaji, T.S.Uma, P.K.Sehgal.
Ph.D Students Guided
  • N. Naveen (2009-2012) Development of polymeric scaffolds for skin tissue regeneration
  • M. D. Raja (2010-2015) Development and characterization of Novel drug delivery systems