CSIR-Central Leather Research Institute
Dr.Uthirappan Mani
Senior Technical Officer (2)
Academic Qualifications
    Ph.D
Contact Details
Dr.Uthirappan Mani
Senior Technical Officer (2)
InCharge Animal House
Bio-Technology
CSIR-Central Leather Research Institute
Adyar, Chennai – 600 020
e-mail: manitoxicology@yahoo.co.in,
Phone:044-24430273 / 24911386


Qualification
 

Ph D (2001), Toxicology, Jamia Hamdard, Hamdard University, New Delhi

M Sc (1991) Environmental Toxicology, University of Madras, Chennai

B Sc (1991) Botany, University of Madras, Chennai

Area of interests
 
  • Toxicological studies
  • microbial and enzyme technology for skins/hides dehairing.

Research Experience

02.01.2009 Onwards: Senior Technical Officer, Biotechnology Laboratory, Central Leather Research Institute, Adyar, Chennai.
  1. Preparation of Collagen based biomaterials for application in tissue engineering and regeneration.
  2. Utilization of tannery solid waste for application in road construction sector
  3. Deposition of new strain at MTCC, IMTECH, Chandigarh:  Novel alkaline protease producing bacteria Bacillus sp. MTCC No. 5468 IDA Patent deposit at IMTECH, Chandigarh.
22.01.1996 to 01.01.2009: Technical Officer at Indian Institute Toxicology Research, (CSIR) Lucknow, U.P, India.. Participated as active member in the following consultancy/sponsored projects for the safety/toxicological evaluation of products/toxicants in different animal models:
  1. 90 day inhalation safety study of micro particle DPI in Rhesus Monkeys (CSIR)
  2. Latent M. tuberculosis: New targets, Drug Delivery Systems, Bio enhancers’ and therapeutics (NMITLI, CSIR)
  3. Inhalation Toxicity studies of Horticultural Mineral Oil (HMO) sponsored by IOC, Faridabad.
  4. Safety evaluation study of Bacillus Bacillus spharicus (SP-80), (DARL, DRDO). 
  5. Bio-Safety evaluation of Entamo-Pathogenic bacterium (SSP-150/08) sponsored by V.P.K. Anusanthan Sanstan, Almora, Utharanchal.
  6. Inhalation toxicity studies of gasoline exhaust (s) in rats and mice
  7. Generation of inhalation toxicity data of microbial pest control agents (DBT, New Delhi)
  8. Screening of plant extracts for manipulation of cytokine network (DBT, New Delhi)
  9. Inhalation toxicity studies of SF6 in mice (BARC, Mumbai).
  10.  Safety evaluation studies of alcohol blended gasoline (s) (IOC, Faridabad)
  11. Toxicological evaluation of FRP pipes (NSL, DRDO, Visakapattinam)
  12. Inhalation toxicity studies of with Mosquito Repellent containing Allethrin (CSIR)
  13. 90 days feeding studies with hybrid cotton seeds in goats (Monsanto-India, Mumbai)
  14. Toxicity of inhaled synthetic pyrethroids with particular reference to Fenvalerate (CSIR)
  15. Inhalation toxicity studies of Trichloroethylene in rats (CSIR)
  16. Inhalation toxicity studies of cadmium chloride in rats (CSIR
Chlor- Alkali Plant (Mercury cells) Pollutant Control and Management, Southern Petro Chemicals Industries Corporation Limited, (SPIC), Chennai, India.
1994-1995: Project assistant in National Environmental Engineering Research Institute (NEERI), (CSIR), Chennai.
 
HRD Activities
  • Supervision of B.Tech/M.Sc/M. Tech/M.Phil Students for project dissertation.

Technologies Developed / Transferrable to INDUSTRY
  • Development of appropriate technology for utilization of fallen carcass.
  • Processing of Animal Byproducts using Biotechnological tools for Animal Feed Industry.
  • Biomass production using Cyanobacteria on effluent Generated from Carcass Recovery Centre.
  • Development of serum based protein binder using bovine serum, a slaughterhouse waste, for leather finishing.
  • Isolation, purification and sequencing of proteases from plant source for lime sulphide free unhairing of hides/skin.


List of Publications
  1. U. Mani, P. Singh, Kewal Lal, and R. C. Murthy. Inhalation exposure of formulated Fenvalerate (20% EC): Toxicologic alterations in kidney of rats. (2007). Bullet in of Environmental Contam. Toxicol. 79:15-19. 
  2. U. Mani, A. K. Prasad, V Suresh Kumar, Kewal Lal, RK Kanojia, B. P. Chaudhari and RC Murthy (2007). Effect of fly ash inhalation on biochemical and histomorphological changes in rat liver. Ecotoxicol. Environment. Safety.  68:126-133.
  3. R. Sharma, P. Muttil, A.B. Yadav, S.K. Rath, V.K. Bajpai, U. Mani and A. Misra (2007). Uptake of inhalable micro particles affects defence responses of macrophages infected with Mycobacterium tuberculosis H37Ra. J. Antimicrobial. Chemotheraphy. 59:499-506.
  4. V. Suresh Kumar, B.N. Paul, U. Mani, Renu Pandey, Kewal Lal, A.K. Prasad, Suresh Srivastava & A.K.Saxena (2005).  Proinflammatory and anti-inflammatory cytokine balance in Gasoline exhaust induced pulmonary injury in mice. Inhalation Toxicology. 17:161-168.
  5. U. Mani, A.K.Prasad, V.Suresh Kumar, P. Kumar, Kewal Lal, B.K.Maji and K.K Dutta. (2004). Hepatotoxic Alterations Induced by Sub chronic Exposure of Rats to Formulated Fenvalerate (20% E.C) by Nose Only Inhalation. Biomed. Environment. Sci, 17:309-314.
  6. U. Mani, F. Islam, A.K. Prasad, P. Kumar, B. K. Maji & K. K. Dutta (2001). Pulmonary toxicity of a formulated preparation of Fenvalerate in rats sub chronically exposed by nose only inhalation for 90 days. Biomed. & Environment Sci. 14: 333-340.
  7. V.Suresh Kumar, U. Mani, A.K.Prasad, Kewal Lal, V.Gowri, and Abhishek Gupta. Effect of fly ash inhalation on biochemical and histomorphological changes in rat lungs (2004.) Indian J. Experimental Biol. 42: 964-968.
  8. U. Mani, A.K. Prasad, Pradeep Kumar, V. Suresh Kumar, Kewal Lal, B. K. Maji and K. K. Dutta (2003). Effects of Formulated Fenvalerate (20% EC) on male mediated Fertility parameters in rats exposed by nose only inhalation J. Ecophysiol. Occup. Hlth: 3: 71-78.
  9. U. Mani, F. Islam, A.K. Prasad, P. Kumar, V.S. Kumar, B.K. Maji & K.K. Dutta (2002). Steridogenic alterations in testes and sera of rats exposed to formulated Fenvalerate by inhalation. Human. Exptl. Toxicol. 21: pp.593-597.
  10. P. Kumar, A.K. Prasad, B. K. Maji, U. Mani & K. K. Dutta (2002). Effect of Tri-Chloroethylene (TCE) inhalation on Biotransformation enzymes of rats lung and Liver. J. Environ. Biol.23: 1-6.
  11. B.N. Paul, A. Prakash, S. Kumar, A.K. Yadav, U. Mani, A.K. Saxena, A.P. Sahu, Kewal Lal & K.K. Dutta (2002). Silica induced early fibrogenic reaction in lung of mice ameliorated by Nyctanthes arbortristis extract. Biomed. Environment. Sci, 15:22-29.
  12. B.N. Paul, A. Prakash, A.K.Yadav, A.K. Saxena, A.P. Sahu, U. Mani & K.K. Dutta (2002). Plant extract mediated modulation of TNF-α in BAL of mice exposed to silica.  J. Med. Aromat. Plant. Sci. 22- 4A: 53-55.
  13. Kumar, D.C. Purohit, A.K. Prasad, B. K. Maji, U. Mani, K. K. Dutta & B.N. Paul. (2002). Histochemical alterations in rat lungs by inhalation of Trichloro ethylene. J. Ecophysiol. Occup. Hlth. 2: 265-274.
  14. K.K. Dutta, F. Islam, U. Mani, A.K. Prasad, P. Kumar, B. K. Maji (2001).  Sub chronic inhalation exposure of rats to formulated Fenvalerate (EC 20%) using Flow Past Nose Only Inhalation Chamber: Some biochemical alterations in lung. Biomedicine. 21: 14-22.
  15. P. Kumar, A.K. Prasad, U. Mani, B. K. Maji & K. K. Dutta (2001). Trichloro ethylene induced testicular toxicity in rats exposed by inhalation. Human & Exptl. Toxicol. 20: 585-589.
  16. P. Kumar, A.K. Prasad, B. K. Maji, U. Mani & K. K. Dutta (2001). Hepatotoxic alterations induced by inhalation of Trichloro ethylene (TCE) in rats. (2001). Biomed. & Environ. Sci. 14: 325-332.
  17. P. Kumar, A.K. Prasad, D.K. Saxena, U. Mani, B.K. Maji & K.K. Dutta (2000). Fertility and general Reproduction studies in TCE exposed rats. Indian J. Occup. Hlth. 43: 117-126.
Abstracts presented in seminars and conferences
  1. Abstract Presented at 44th LERIG 2010 on “isolation of tannery effluent borne bacterial colonies and studies on their Cr (VI) tolerance held at CLRI, from 29 & 30th Jan. 2010.
  2. Paper presented at 50th Annual Conference of Association of Microbiologists of India on “UV radiation induced mutation of a novel Bacterium (MRCC 5468) for enhanced protease production and its application in Leather processing industry” held at NCL, Pune from 15-18, Dec. 2009.
  3. Fareed, M., Pathak, M.K., Bihari, V., Mani, U., Bharti, R.S., Patel, D.K., Kesavachandran, C., Mathur, N. Association of incorrect work practices, exposure period and predictors for abnormal haematology in pesticide exposed population; 28th Ann. Conf. of Soc. of Toxicology (STOX), Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana (Punjab), October 2008.
  4. Pathak, M., Fareed, M., Kumar, R., Patel, D.K., Mani, U., Bihari, V., Kesavachandran, C., Mathur, N. Agricultural health study among farmers with special emphasis on pesticide exposure. XXVII Ann. Conf. of Society of Toxicology, India, held at Bangalore, October 8-12, 2007, Pp. 131-132.
  5. Mani U, Chudhari B. P. Prasad, A.K, Lal Kewal, D.K. Patel, Singh, PK and Paul, B.N. Hepatic and renal toxicity of gasoline exhaust (GE) following sub acute inhalation exposure in mice. Abstract presented at National Cell Biology Conference & Symposium on Environment & Chemical Interaction at ITRC, Lucknow, During Jan. 17-20, 2006, Pp.64.
  6. Mani U, Prasad, A.K, Lal Kewal, and Chudhari B. P. Pathobiochemical alterations in the kidney of rats following inhalation exposure of formulated Fenvalerate (20% E.C). Abstract presented at International Conference on Toxicology, Environmental and Occupational Health at ITRC, Lucknow, During November 14-17, 2005. Pp.42.
  7. Kewal Lal, U. Mani, Nrashant Singh, P.K. Singh and R.C. Murthy. Toxicity of biomass fuel, cow dung (Kanda) smoke on different vital organs of rats.XXVII Annual Conf. of Society of Toxicology, India, held at Bangalore, October 8-12, 2007, pp. 85
  8. Kewal Lal, U. Mani, A.K. Prasad. Biomass fuel combustion alterations in the Broncho alveolar lavage fluid cells of rat. Abstract presented at Int. Conf. on Toxicology, Toxicogenomics and occupational health, Oct. 9-11, 2006, Gwalior, M.P.
  9. Prasad, A.K, Mani U, Lal K, R.K., Kanojia, B.P. Chaudhari and R.C. Murthy. Inhalation induced changes on biochemical and histopathological alterations in rat liver exposed to fly ash. Abstract presented at International Conference on Toxicology, Environmental and Occupational Health at ITRC, Lucknow, During November 14-17, 2005. Pp. 43.
  10. Kewal Lal, U. Mani, A.K. Prasad. Histopathological alterations in the kidney of rats exposed to fly ash. Abstract presented at International Conference on Toxicology, Environmental and Occupational Health at ITRC, Lucknow, During November 14-17, 2005. Pp. 42
  11. Kewal Lal, A.K. Prasad, V. Suresh Kumar, U. Mani, and G.S.D. Gupta. Comparative histopathological region of rat following sub chronic exposure to biomass fuel. Abstract presented at International Symposium on Molecular Toxicology and Environmental Health at ITRC, Lucknow, During November 5-8, 2003.
  12. V. Suresh Kumar, B.N. Paul, U. Mani, A.K. Prasad, P.Gautam, Kewal Lal, A.P.Sahu, A.K.Saxena, Q. Rahman. Proinflammatory and anti-inflammatory cytokine balance in BALF of mice exposed to gasoline exhaust. A paper presented at 22nd annual conference of STOX at Madras Veterinary College, Chennai, Tamil Nadu, during November 20th-22nd 2003.
  13. Raini Dutta, U.Mani, A.K.Prasad, K.P.Singh, S.B.Vohara & K.K.Dutta. Short-term toxicity studies of orally administered chromium in rats through drinking water. XIX STOX Conf. held at Palampur (H.P) during 9-10th Nov.2002, pp.56-57.
  14. B.N. Paul, A. Prakash, S. Kumar, A.K.Yadav, U. Mani, A.K. Saxena, A.P. Sahu, Kewal Lal & K.K. Dutta. Nyctanthes arbortristis mediated modulation of TNF-α in BAL of mice exposed to silica. Int. Conf. on Environmental and Occupational Respiratory Diseases” held at ITRC, during Oct. 29 – Nov. 02, 2000, pp. 106.
  15. K.K. Dutta, U. Mani, A.K. Prasad, Pradeep Kumar & B. K. Maji. “Studies on Fenvalerate (EC 20%) induced pulmonary toxicity in rats sub chronically exposed by inhalation”. Int. Conf. on Environmental and Occupational Respiratory Diseases” held at ITRC, during Oct. 29 – Nov. 02, 2000, pp. 98.
  16. A.K. Prasad, U. Mani, P. Kumar & K. K. Dutta.  Pulmonary toxic effects on Allethrin containing liquid mosquito repellent (ACLMR) in rats “Int. Conf. on Environmental and Occupational Respiratory Diseases” held at ITRC, during Oct. 29 – Nov. 02, 2000. pp 103-104.
  17. A.K. Prasad, P. Kumar, U. Mani, K. K. Dutta. Effect of Allethrin – Based liquid mosquito repellent inhalation on pulmonary damage in developing rats. Paper presented at 18th Ann. conf. of STOX, India held a VCRI, Namakkal, Tamil Nadu during Nov. 11-13, 1999, pp.28-29.
  18. B.Ranganathan, R. Swaminathan, V. Kothandaraman, U. Mani & N. Jothi Kumar. Studies on the solid waste management in a potassium chlorate manufacturing industry. VI National convention of electrochemist at Karikudi, (T.N), during Dec 20-21, 1995, pp.31.