CSIR-Central Leather Research Institute
Dr.N Ayyadurai
Senior Scientist
Academic Qualifications
    Ph.D, Pondicherry University
Contact Details
Dr.N Ayyadurai
Senior Scientist

Bio-Technology
CSIR-Central Leather Research Institute
Adyar, Chennai – 600 020
e-mail: ayyadurai@clri.res.in,
Phone:91 44 24437136


Qualification
 

Ph.D. in Biotechnology : 2001-2006, Pondicherry University (Central University), Pondicherry, India

Master in Microbiology : 1998-2000, Madurai Kamaraj University, Madurai, Tamil Nadu, India

Area of interests
 
  • Proteomic and genomics approach in pre and post tanning process;,
  • expanding and engineering the genetic code tools in leather processing and enzyme engineering

Professional Experience

August 2013 Senior Scientist, Department of Biotechnology. Central Leather Research Institute, Adyar, Chennai
2012-21013 Assistant Professor, Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia
2009- 2012 Assistant Foreign Professor, School of Biotechnology, Yeungnam University, South Korea
2007-2009 Postdoctoral Researcher, Division of Bimolecular Engineering, Pusan National University, S.Korea
2006-2007 Invited Scientist, Biocentre division, Korea Polar Research Institute (KOPRI), S, Korea
2001-2006 Ph.D. in Biotechnology, Pondicherry Central University, India

Membership in Society

  • Member of the protein Society, United States of America
  • Editorial Board Member in Research Journal of Biotechnology [SCIE journal]
  • Member of Korean Biotechnology and Bioengineering society [KSBB]
  • Member of Biotech Research Society of India [BRSI]
  • Member of Association of Microbiologist in India[AMI]
  • Member of Korean Chemical Society in Republic of Korea
Teaching Experience
2009- 2012

Teaching various subject to undergraduate and master students in School of Biotechnology Yeungnam University, Gyeongsan, South Korea.

Course: Special Course in Biotechnology, Biochemistry, Molecular Biology, Biochemistry

2001-2006 Responsible for Microbiology and Molecular biology Practical course for Department of Biotechnology, Pondicherry University, India and supervised Master student thesis projects.
Publications
  • Yang B, Ayyadurai N, Yun H, Choi Y. S, Hwang B. H, Huang J, Lu Q, Zeng H, Cha HJ. (2014). In vivo residue-specific Dopa-incorporated engineered mussel bioglue with enhanced adhesion and water resistance. Angew Chemie Int. Ed. (In Press). [Impact factor 13.7]

  • Deepankumar K, Prabhu NS,  Ayyadurai N, Song E, Lee N, Kim SK, Kim BG, Soundrarajan N, Lee S, Cha HJ, Budisa N, Yun H. (2014). Enhancing thermostability and organic solvent tolerance of ω-transaminase through global incorporation of fluorotyrosine. Advanced Synthesis and Catalysis. 356: 993-998. [Impact factor 5.5].

  • Deepankumar K, SP Nadarajan, N. Ayyadurai, Yun H. (2013). Enhancing the biophysical properties of mRFP1 through incorporation of fluoroproline. Biochem Biophys Res Commun440:509-414. [Impact factor 2.4]

  • N. Ayyadurai, N. SaravananPrabhu, K. Deepankumar, Heon-Ho Jeong, Chang-Soo Lee, S. G. Lee, and H. Yun. (2011). Genetic incorporation of metal binding site in green fluorescent protein for development of selective, sensitive and reversible protein based biosensor. AngewChemie Int. Ed.50:6534-6537[Impact factor 13.7]
  • N. Ayyadurai, K. Deepankumar, N. SaravananPrabhu, S. G. Lee, and Hyungdon Yun. (2011). A facile and an efficient method for the incorporation of multiple unnatural amino acids into a single protein. ChemComm. 47:3430-3432. [Impact factor 6.3].
  • N. Ayyadurai, N. SaravananPrabhu, K. Deepankumar, Jang YJ, Chitrapriya N, Song E, Lee N, Kim SK, Kim BG, Soundrarajan N, Lee S, Cha HJ, Budisa N and Yun H. (2011).Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide. Biconjugate Chem. 22; 551-555. [Impact factor 4.5].
  • N. SaravananPrabhu, N. Ayyadurai (Equally contributed), K. Deepankumar, T. Chung, D. Joon Lim, H. Yun.(2012). Reassignment of sense codons: Designing and docking of proline analogs for Escherichia coli prolyl-tRNAsynthetase to expand the genetic code. J. Mol. Catal. B: Enzym 78: 57–64. [Impact factor 2.8].
  • S. Nagasundarapandian, L. Merkel, N. Budisa, R. Govindan, N. Ayyadurai, S. Sriram, H. Yun, S. G. Lee. (2010). Engineering protein sequence composition for folding robustness renders efficient non-canonical amino acid incorporations. Chembiochem. 11:2521-2524. [Impact factor 3.7].
  • N. Ayyadurai, K. Deepankumar, N. SaravananPrabhu, N. Budisa, and H. Yun. (2012). Evaluation and biosynthetic incorporation of chlorotyrosine into recombinant proteins. Biotechnol. Bioprocess Eng.17: 679-686. [Impact factor 1.2].
  • N. Ayyadurai, N. SaravananPrabhu, K. Deepankumar, S. G. Lee, and Hyungdon Yun. (2011). Biosynthetic substitution of tyrosine in green fluorescent protein with its surrogate fluorotyrosine in Escherichia coli. Biotechology Letters. 33:2201-2207. [Impact factor 1.8].
  • N. Soundrarajan, S. Edwardraja, Sun-Gu Lee, H. Yun, N. Ayyadurai. (2012) Enhancing the productivity of soluble green fluorescent protein through methionine-residue specific consensus approach. Afr. J. Biotech. 11:1059-1064.[Impact factor 0.6]
  • Chenniappan K, N.Ayyadurai (Equal contributed). (2012). Synergistic activity of Cyt1A from Bacillus thuringiensis subsp. israelensis with Bacillus sphaericus B101 H5a5b against Bacillus sphaericus B101 H5a5b-resistant strains of Anopheles stephensi Liston (Diptera: Culicidae). Parasitology Research.110: 381-388. [Impact factor 2.8].
  • N. RameshKumar, N. Ayyadurai(Equally contributed), N. Kayalvizhi1, P. Gunasekaran.(2012). Genotypic and phenotypic diversity of PGPR fluorescent pseudomonads isolated from the rhizosphere of sugarcane (Saccharumofficinarum L.). J. Microbiol. Biotech.22:17-28 [Impact factor 1.7]
  • J. Pathma, N. Ayyadurai, N. Sakthivel. (2010). Assessment of genetic and functional relationship of antagonistic fluorescent pseudomonads of rice rhizosphere by repetitive sequence, protein coding sequence and functional gene analyses. J. Microbiol. 48:715-727.[Impact factor 1.2].
  • N. Ayyadurai, H.Yun, S. G. Lee. (2010). Role of Chaperon Co-Expression System in the Production of Recombinant Unnatural Proteins in Escherichia Coli. Res. J. Biotech. 5:49-53.[Impact factor 0.28].
  • N. Ayyadurai,ValarmathyNatarajan and H. Yun. (2010). Effect of IndigoferaTinctoria against carbon tetrachloride induced hepatic damage in albino rats. Res. J. Biotech. 5: 5-8.[Impact factor 0.28].
  • N. Ayyadurai, H. Yun, and S. G. Lee. (2009). Application of Expanding the Genetic Code: Res. J. Biotech. 4: 76-77.[Impact factor 0.28].
  • N. Ayyadurai, So Yeon Kim, and S. G. Lee. (2009). Biological Synthesis of Alkyne-terminated Telechelic Recombinant Protein. Macromolecular Res. 17: 424-429.[Impact factor 1.6].
  • N. Ayyadurai,N. Ramesh Kumar, N. E. Selvakumar, R. Sundar and S. G. Lee. (2009).Importance of expression system in the production of unnatural recombinant proteins in Escherichia coli.Biotech. Bioproc. Eng. 14: 257-265.[Impact factor 1.0].
  • RavindraNaik, NirakarSahoo, DevrishiGoswami, N. Ayyadurai,N. Sakthivel (2008). Assessment of genetic and functional diversity among fluorescent pseudomonads isolated from the rhizosphere of banana. Microbial Ecol. 56: 492-504.[Impact factor 2.8].
  • So-yeon Kim, N. Ayyadurai,Mi-aeHeo, Sunghoon Park, Yong joojeong and S. G. Lee. (2008) Improve the thermo tolerance of Escherichia coli by over expressing GroELS. J. Microbiol. Biotech 19: 72-77.[Impact factor 1.2].
  • N. Ayyadurai, P. RavindraNaik and N. Sakthivel. (2007). Functional characterization of antagonistic fluorescent pseudomonads associated with rhizospheric soil of rice (Oryza sativa L). J. Microbiol. Biotech17:919-927.[Impact factor 1.0].
  • N. Ayyadurai, P. RavindraNaik, M. SreehariRao, R. Sunish Kumar, Subodh Kumar Samrat, M. Manohar, N. Sakthivel. (2006) Isolation and characterization of a novel banana rhizosphere soil bacterium as fungal antagonist and microbial adjuvant in micropropagation of banana. J. Appl.Microbiol. 100:926-937.[Impact factor 2.3].
  • VirBahadur Singh, Anil Kumar, S. Isaac Kirubakaran, N. Ayyadurai, R. Sunishkumar and N. Sakthivel. (2006). Comparison of exopolysaccharides produced by Xanthomonasoryzaepv. oryzae strains, BXO1 and BXO8 that show varying degree of virulence in rice (Oryza sativa L.). J. Phytopathol. 154: 410-413.[Impact factor 0.9].
  • N. Ayyadurai, S.IssacKirubakaran, S.Srisha, N. Sakthivel. (2005) Biological and Molecular variability of Sarocladiumoryzae, the sheath rotpathogen of rice (Oryza sativa L.) Current Microbiol. 50:1-6.[Impact factor 1.5].
  • R. Sunish Kumar, N. Ayyadurai, P.Pandiaraja, A. V. Reddy, Y. Venkateswarlu,Om Prakash,N. Sakthivel. (2005) Characterization of antifungal metabolite produced by a new strain Pseudomonas aeruginosaPUPa3 that exhibits broad-spectrum antifungal activity and biofertilizing traits. J. Appl. Microbiol. 98: 145-154. [Impact factor 2.3].
  • S. Datta, R. Sunish Kumar, N. Ayyadurai, Sujeet Kumar, N. Sakthivel. (2004) Polysaccharides of Pseudomonas pathovar strains that infect pea, tomato and soya bean. Current Microbiol.49:35–41. [Impact factor 1.5].
Patent
  • 3,4-dihydroxy-L-phenylalanine incorporation for protein based biosensor generation; April, 2011, Patent Number: DP110321KR, South Korea
  • Protein polysaccharide conjugation by invivo incorporation of 3,4-dihydroxy-L-phenylalanine into proteins. April, 2011, Patent Number: DP110322KR, South Korea.

Awards & Honours Received

  • Finn Wold Travel award offered by The Protein Society to attend 25th anniversary symposium of the protein society is held in Boston, United States of America (USA)(2011).
  • International Speaker award to attendInternational conference on Greenomics arranged by School of Life Sciences, Hindustan University, Chennai, India. (2010)
  • Welcome trust international travel award to attend Open door workshop in Bangkok. (2009.)
  • International Postdoctoral Fellowship award from Korean science and Engineering, (KOSEF) S. Korea (2008).
  • University Postdoctoral Fellow award from Pusan National University, S. Korea (2007).
  • Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India (2005 - 2006).
  • Research Fellowship from University Grant Commission, Government of India (2001-2004)
  • Mayhco Research Fellowship Award for Attending International Conference, India (2005).
Student Guidance
  • Ph.D thesis guidance: Currently, I am guiding for five PhD students in Prof. Hyungdon Yun Laboratory. Five students are working in different biomedical projects to develop protein based biosensor, enhancing the protein functionality, searching new active compound, fungal p450 enzymes and metabolic engineering.
  • Master thesis guidance: During my PhD, I guided around five master students in genetic diversity of fluorescent pseudomonads. Most of the students are published their result in well reputed journals.
Student Guidance
  • Ph.D thesis guidance: Currently, I am guiding for five PhD students in Prof. Hyungdon Yun Laboratory. Five students are working in different biomedical projects to develop protein based biosensor, enhancing the protein functionality, searching new active compound, fungal p450 enzymes and metabolic engineering.
  • Master thesis guidance: During my PhD, I guided around five master students in genetic diversity of fluorescent pseudomonads. Most of the students are published their result in well reputed journals.