CSIR-Central Leather Research Institute
Dr.M. Shanmugavel
Senior Technical Officer (2)
Academic Qualifications
    Ph.D. Jiwaji University
Contact Details
Dr.M. Shanmugavel
Senior Technical Officer (2)

Biological Material Laboratory
CSIR-Central Leather Research Institute
Adyar, Chennai – 600 020
e-mail: shanmugavel_m_2001@yahoo.com,
Phone:+ 91-44-24422024


Qualification

  Ph D (2011) in Zoology from Jiwaji University, Gwalior, Madhya Pradesh.

     M.Sc (1990) in Zoology from Madurai Kamaraj University, Tamil Nadu.

     B. Sc (1977) in Zoology from Madurai Kamaraj University, Tamil Nadu

Area of Interest:
 
  • Microbial enzyme production and its application
  • Bioprocesses technology and in-vitro cell culture studies on human cancer cell lines.
Title of the Ph.D thesis
 

Anticancer activity of some potential Indian Medicinal plants

Scientific contribution
  Microbiology
 

The enzyme  consortium was prepared from the Aspergillus fungus  and it was also used for processing of sheep and goat skin as well as cow and buffalo hides without the use of chemicals. The pollution parameters were reduced upto 40- 60% and there is reasonable reduction in water consumption, wastewater discharge, when compared to the conventional leather processing.

  Cancer – Drug development  
 

In the area of anticancer drug development number of hits/ leads have been identified such as AP9cd, RJM 0125 P04 A003, SS-157, SS176 etc. These are being actively followed for drug development.

Research Papers published

 
  1. Asama Mukherjee, Suva Hazra, Sushanta Dutta, Shanmugavel Muthiah, Dilip Manikrao Mondhe, Parduman Raj Sharma, Shashank Kumar Singh, Ajit Kumar Saxena, Gulam Nabi Qazi and Utpal Sanyal. Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents. Investigational New Drugs, Volume 29, Number 3, 434-442 (2011)
  2. Asama Mukherjee, Sushanta Dutta1, Muthiah Shanmugavel, Dilip M Mondhe, Parduman R Sharma, Shashank K Singh, Ajit K Saxena, Utpal Sanyal.  6-Nitro-2-(3-hydroxypropyl)-1H-benz[de] isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis. Journal of Experimental & Clinical Cancer Research, 29:175. (2010) 
  3. Parduman R. Sharma, Dilip M. Mondhe, Shanmugavel  Muthiah, Harish C. Pal, Ashok K. Shahi, Ajit K. Saxena, Ghulam N. Qazi. Anticancer activity of an essential oil from Cymbopogon flexuosus .  Chemico-Biological Interactions (179) 160-168. (2009)
  4. P. R. Sharma, M. Shanmugavel, A. K. Saxena and G. N. Qazi. Induction of Apoptosis by a synergistic lignan composition from Cedrus deodara in human cancer cells. Phytotherapy Research  22, 1587–1594. (2008)
  5. S. K. Singh, M. Shanmugavel, H. Kampasi, D. M. Mondhe, J. M. Rao, M. K. Adwankar, A. K. Saxena, G. N. Qazi. Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity. Planta Medica  73: 519-526. (2007)
  6. R. Singh, S. S. Bhella, A. K. Saxena, M. Shanmugavel,  A. Faruka and M. P. S. Isher, Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen Tetrahedron 63:  2283–2291. (2007)
  7. V. Dhuna, S. S. Kamboj, A. Kaur, A. K. Saxena, S. V. Bhide, M. Shanmugavel,  J. Singh. Characterization of a Lectin from Gonatanthus pumilus D. Don Having Anti-Proliferative Effect Against Human Cancer Cell Lines. Protein and Peptide Letter, 14: 71-78 (2007)
  8. A. Pain, S. Samanta, S. Dutta, A. K. Saxena, M. Shanmugavel, M. Sharma, G. N. Qazi and U. Sanyal. Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds Acta Poloniae Pharmaceutica / Drug Research 64: 27-33. (2007)
  9. A. Kaur, J. Singh, S. S. Kamboj, A. K. Saxena, R. M. Pandita and M. Shamnugavel, Isolation of an N-acetyl-D-glucosamine specific lectin from the rhizomes of Arundo donax with antiproliferative activity. Phytochemistry 66: 1933-1940. (2005)
  10.  B. A. Bhat, K. L. Dhar, S. C. Puri, A. K. Saxena, M. Shanmugavel and G. N. Qazi. Synthesis and Biological evaluation of Chalcones and their derived pyrazoles as potential cytotoxic agents. Biorganic Medicinal Chemistry Letters 15: 3177-3180. (2005)
  11. S. Samanta, A. Pain, S. Dutta, A. K. Saxena, M. Shanmugavel, R. M. Pandita, G. N. Qazi and U. Sanyal.  Antitumor activity of Nitronaphthal-NU, a novel mixed function agent. Journal of Experimental Therapeutics and Oncology 5: 15-22. (2005)
  12. A. Kamal, R. Ramu, G. B. R. Khanna, A. K. Saxena, M. Shanmugavel and R. M. Pandita. Pyrrolo[2,1-c][1,4] benzodiazepine – anthraquinone conjugates -  Synthesis, DNA binding and cytotoxicity. Bioorganic & Medicinal Chemistry Letters 14: 4907-09. (2004)
  13. A. Pain, S. Samanta, S. Dutta, A. K. Saxena, M. Shanmugavel, H. Kampasi, G. N. Qazi and U. Sanyal.  Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide, as a rationally designed anticancer agent. J Exp. Clin. Cancer Res. 22: 411-418. (2003)
  14. A. Pain, S. Samanta, S. Dutta, A. K. Saxena, M. Shanmugavel, H. Kampasi, G. N. Qazi and U. Sanyal.  Synthesis and evaluation of substituted naphthalimide nitrogen mustards as a rationally designed anticancer compounds. Acta Poloniac. Pharmaceutica Drug Res. 60: 285 – 291. (2003)
  15. J. L. Koul, S. Koul, C. Singh, S. C. Taneja, M. Shanmugavel, H. Kampasi, A. K. Saxena and G. N. Qazi. In vitro cytotoxic elemanolides from Vernonia lasiopus. Planta Med. 69: 164-6 (2003)
  16. A. Pain, S. Samanta, S. Dutta, A. K. Saxena, M. Shanmugavel, H. Kampasi, G. N. Qazi and U. Sanyal.  Evaluation of napromustine, a nitrogen musturd derivative of naphthalimide, as a rationally designed mixed-function anticancer agent. Experimental Oncology 24: 173-179 (2002)
  17. S. Samanta, A. Pain, S. Dutta, A. K. Saxena, M. Shanmugavel, H. Kampasi, G. N. Qazi and U. Sanyal. Evaluation of a series of 2-chloroethylnitrosourea derivatives of substituted naphthalimides as mixed-function antitumor agents. International J. of Cancer  13 (Supl.): 434 (2002)
  18. Kachroo, J. L., Shanmugavel, M and Bhan, M.K. Effect of Micro-nutrients on the yield of Pleurotus sajor-caju (Fr)& Singer. J. Mycology and Plant Pathology 28(1), 59-61. (1998)
  19. Kachroo, J. L., Shanmugavel, M and Bhan, M.K. Effect of NPK  fertilizers on the production of Pleurotus sajor-caju (Fr)& Singer.J. Mycology and Plant Pathology 27(2), 232-233. (1997)
 

Patents

  US Patents Granted
 
  1. Herbal chemical composition for the treatment of cancer.
    J M Rao, P V Srinivas, J S Yadav, K V Raghavan, A K Saxena, M. Shanmugavel, H. Kampasi, and G N Qazi.
    US 7,285,571 dated October 23, 2007
  2. Herbal chemical composition for the treatment of cancer.
    J M Rao, P V Srinivas, J S Yadav, K V Raghavan, A K Saxena, M Shanmugavel, H Kampasi and G N Qazi.
    US 6,649,650 dated November 18, 2003
  Patents filed
 
  1. Bioactive extract & fraction from Butea monosperma for the treatment of hepatocellular carcinoma.
    A K Saxena, B D Gupta, B K Kapahi, M Shanmugavel, D M Mondhe, G N Qazi, V Kumar and G Mathen.
    Indian Patent: 0438 NF 2004; 01356 DEL 2005 dated 24th May 2005
    PCT application: PCT/IB06/01355 dated 24th May 2006
    US Patent: Application No. 11/440,790 dated 25th May 2006; PGPUB: 20060280817 dated 14th Dec. 2006.
  2. A novel herbal chemical composition for the treatment of cancer.
    J M Rao, P V Srinivas, J S Yadav, K V Raghavan, A K Saxena,  M Shanmugavel, H Kampasi, and G N Qazi.
    Indian Patent: 0439 NF 2001; 01837 DEL 2003
    PCT application: PCT/IN 01/0214.
  3. Cytotoxicity and anti-cancer activity of essential oil from Cymbopogon flexuosus (nees ex steud.) Wats.
    S C Taneja, J Singh, A K Saxena,  A K Shahi, V K Sethi, D M Mondhe, S Singh, M K Koul, S Chandra, S S Andotra, A Kumar, S Bhushan, S K Singh, M Shanmugavel, P R Sharma and G N Qazi.
    Indian Patent: 0125 NF 2006 dated 26th April 2006; 1322 DEL 2007 dated 19th June 2007.
  4. Cytotoxicity and anti-cancer activity of novel semi-synthetic analogues of sesquiterpene lactone parthenin for its usefulness as anti-cancer agent.
    G N Qazi, S C Taneja, J Singh, A K Saxena, V K Sethi, B A Shah, A Kumar, S S Andotra, F Malik, M Shanmugavel and S K Agrawal.

    Indian Patent: 0207 NF 2006 dated 11th Sep. 2006; 0839 DEL 2008 dated 31st March 2008.
  5. Cytotoxicity and induction of apoptosis in cancer cells by semi-synthetic analogues of boswellic acids for their use as anti-cancer agents.
    G N Qazi, S C Taneja, J Singh, A K Saxena, V K Sethi, B A Shah, B K Kapahi, S S Andotra, A Kumar, S Bhushan, F Malik,, D M Mondhe, M Shanmugavel and S Singh, M Verma and S K Singh.
    Indian Patent: 0201 NF 2006 dated 1st Sep. 2006; 0606 DEL 2008 dated 11th March 2008
  6. A novel standardized synergistic pharmaceutical formulation with th 1- dominant immune up regulating and anticancer activities.
    G N Qazi, J Singh, F Malik, A K Saxena, K A Suri, N K Satti, Arum Kumar, Ajay Kumar,  S Bhushan, I Khan, D M Mondhe, M Shanmugavel, H C Pal, A Gupta, M Kumar, S Sharma and S Singh.
    Indian Patent: 202 NF 2006 dated 6th Sep.2006; 1321 DEL 2007 dated 19th Jun 2007
  7. Novel substituted 1H-benz[de]isoquinoline-1,3-diones as anticancer agents.
    G N Qazi, A K Saxena, M Shanmugavel, D M Mondhe, P R Sharma, S K Singh, U Sanyal, A Mukherjee, S Hazra  and S Dutta. 
    Indian Patent: 0006 NF 2006 dated 12th January 2006; 0072 DEL 2007 dated 11th January 2007
  8. Semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against anti-cancer cell lines and activity.
    G N Qazi, S C Taneja, J Singh, A K Saxena, V K Sethi, B A Shah, A Kumar, S S Andotra, F Malik, M Shanmugavel and S K Agrawal.
    Indian patent: 0062 NF2008 dated 24th March 2008; 0840 DEL 2008 dated 31st March 2008.

Papers presented at conferences and abstracts published in their proceedings

 

International Conferences

  1. M. Shanmugavel, S. F. Lesley Sounderraj,  A. Dayanandan, A. Premalatha, A. Gnanamani,  A. B. Mandal, G. Suseela Rajakumar. Influence of metal ions on production and stability of alkaline protease by  Aspergillus tamarii for application in leather processing. VIIth Asia International conference on Leather science and technology, held at Kolkatta on 12th – 14th November 2010.
  1. A. Mukherjee, S. Hazra, S. Dutta, A. K. Saxena, M. Shamnugavel, D. M. Mondhe, P. R. Sharma, S. K. Singh, G. N. Qazi and U. Sanyal. Evaluation of antitumor efficacy and apoptotic activity of novel substituted 1H-benz[de]isoquinoline-1,3-diones. International Symposium on Translational Research in Cancer, Bhubaneswar January 17-19, 2007. Abstract # A 16, P. 96.
  2. Shanmugavel M, Gupta B D, Singh S  K, Sharma P  R and Saxena A K  (2006). “Anticancer effect of Apium graveolens Linn seeds against Human cancer cell lines.” International Conference on Toxicology, Toxicogenomics and Occupational Health (ICTTOH), October 9-11, 2006 in Jiwaji University, Gwalior, India.
  1. A.K. Saxena, M. Shamnugavel, S. K. Singh, D. M. Mondhe, P. R. Sharma and G. N. Qazi. Anticancer Potential of Stem Wood of Cedrus deodara. International Conference on Toxicology, Toxic genomics and Occupational Health, October 9-11, 2006, Jiwaji University, Gwalior. Abstract #  PL4, P. 3. 
  1. A. K. Saxena, M. Shanmugavel, D. M, Mondhe, S. K. Singh, J. Singh and G. N. Qazi. Prospecting biodiversity for its anticancer activity, Indo-UK Seminar entitled “Biomarkers of Ecotoxicity, Cancer Monitoring and Prevention” held at Jamia Hamdard (Hamdard University), New Delhi;  August 29, 2004, P. 36.
  1. S. Samanta, A. Pain, S. Dutta, A. K. Saxena, M. Shanmugavel, H. Kampasi, G. N. Qazi and U. Sanyal. Evaluation of a series of 2-chloroethylnitrosourea derivatives of substituted naphthalimides as mixed-function antitumor agents. 18th UICC International Cancer Congress, June 30 - July 5, 2002; Oslo (Norway), International J. of Cancer, Supl. 13, Abstract # P954
 

National Conferences

  1. A. Dayanandan; A. Gnanamani; M. Shanmugavel ;  A. Premalatha ; K. Vijayalakshmi ; S. Hilda Vimala Rani ; S. F. Lesley Sounderraj; G. Suseela Rajakumar. Hydrolysis of  tannery fleshing using enzymes: A biotechnological approach for solid waste management. 44th LERIG held at CLRI, Chennai during 29th & 30th January 2010.
  2. M. Shanmugavel, A. Gnanamani   and G. Suseela Rajakumar. Sulphide free dehairing of skin and hides using alkaline protease of A. tamarii.  LERIG 2009 held on CLRI, Chennai 29-30th January 2009
  3. A.Gnanamani, M. Shanmugavel, K. Vijayalakshmi, L. Sadasiva Sastry, A.Shanmuga Sundaram, S. Jawahar  and G. Suseela Rajakumar Scale up studies using Solid State Fermentation for production of alkaline protease and preparation of spray dried enzyme formulation for leather processingl LERIG 2009 held on CLRI, Chennai 29-30th January 2009
  4. D.S. Mahadevan,  B. Dhandapania and Shanmugavel Muthiah. Bio-calorimeter: smart system to control fermenter for protease production from Aspergillus tamarii. Abstracts of the 14th European Congress on BiotechnologyBarcelona, Spain 13–16 September, 2009. New Biotechnology, Volume 25, Supplement 1, September 2009, Page S195
  5. P. R. Sharma, M. Shanmugavel, A. K. Saxena, and G. N. Qazi. Induction of Apoptosis by a Synergistic Lignan Composition from Cedrus deodara in  Human Cancer Cells. National Conference of Electron Microscopy & XXIX Annual Meeting of Electron Microscopy Society of India (EMSI-2007) at University of Delhi, North Campus, New Delhi, November 26-28, 2007.
  6. V. K. Sethi, S. Singh, B. A. Shah, M. Shanmugavel, A. K. Saxena, S. C. Taneja and G. N. Qazi. Parthenin analouges as cytotoxic agents. 1st J&K State Science Congress, February 7-9, 2005, University of Jammu, Jammu. Abstract CP-64; p 67.

Awards


Most cited paper 2005- 2008 Award

Bioorganic & Medicinal Chemistry Letter Most cited paper 2005- 2008 Award for paper entitled   Synthesis and biological evaluation of chalcone analogues  and their derived pyrazoles as potential cytotoxic agents.
B.A. Bhat, K. L Dhar, S.C Puri, A.K. Saxena,  M.Shanmugavel and G.N. Qazi Bioorganic& Medicinal Chemistry Letters (2005)  15 3177-3180.


Ist prize for the best poster presentation in biological sciences in LERIG 2008 held on CLRI, Chennai 30th January 2008.

Lesely Sounderraj, R. Judith, K. Vijayalakshmi, Hilda Vimala Rani, M. Shanmugavel and G. Suseela Rajakumar. Bioprocessing of animal hides and skins: Process optimization for production of unhairing enzyme in leather processing by submerged and solid state fermentation.

 


2nd Best Paper award 2004- 2005 of Regional Research Laboratory, Jammu (26th September 2005).

B.A. Bhat, K. L Dhar, S.C Puri, A.K. Saxena, , M.Shanmugavel and G.N. Qazi Synthesis and biological evaluation of chalcone analogues  and their derived pyrazoles as potential cytotoxic agents. Bioorganic& Medicinal Chemistry Letters 15 (2005) pp 3177-3180


2nd Best Paper award 2003- 2004 of Regional Research Laboratory, Jammu (26th September 2004).

Koul, J. L., Koul, S., Singh, C., Taneja, S. C., Shanmugavel, M., Himani Kampasi., Saxena,A.K, and Qazi, G. N.( 2003) Potential anticancer elemanolides from  vernonia lasiopus. Planta Medica,(69) 1-3