Serosa membrane of cattle intestine is made free from non-collagenous impurities by treating with wetting agent,proteolytic enzyme and acid and the resulting pure collagenous material is stabilised by a suitable crosslinking agent followed by sterilisation and subsequent ampouling. Being of collagenous origin, the collagen sheet is very much useful as a temporary biological cover for all types of wounds including open raw areas, burns of first, second or third degree, tropical ulcers, leprosy ulcer, thermal wounds etc. The sheet provides economical and effective option for reducing fluid loss as well as pain to minimum by controlling the infection immediately. The product has been commercialized and already been in market.
Reconstituted Collagen sheet
Reconstituted Collagen sheet (RCS) is non-immunogenic, semitransparent cover, which seals the wound while breathing like skin, thereby healing without scar formation. Bovine achilles tendon is solubilised by mechanical, enzymatic and chemical treatment and the pure soluble collagen is purified by successive precipitations at acidic/alkalinne pH. The pure soluble collagen is cut into sheets, crosslinked with UV/GTA and sterilised after dry packaging. Unlike collagen sheet, it sticks over the wounds very easily, whereby the progress of wound healing can be monitored easily from outside because of the semi-transparent nature of the sheet. It is an ideal skin substitute for the management of first and second degree of non-infected burns, raw areas caused by release of burns contractures, traumatic loss of skin cover, skin donor sites, amputation sites, chronic skin ulcers, shallow pressure sores and dermabrasion cases. In third degree burns they are useful as a temporary cover after escharectomy/tangential excision.The RCS can be reconstituted into membrane and sponge material. The technology has already been transferred.
Plant based Reconstituted Collagen Substratum
he substratum, which contains plant based extracts, has enormous application as biological cover for non-healing ulcers as well as burns. The membrane contains active constituent that can serve as a biological cover and enhance the healing of damaged or burnt or non-healing ulcers. The plant based product contains fibroblast growth factor (FBF), keratinocyte growth factor (KGF) that can stimulate proliferation of fibroblasts and keratinocytes. The membrane contains antimicrobial, antiviral properties to retard or eliminate infectious pathogens. The technology is protected by patent.
Collagen scaffold for controlled drug delivery
The technology relates to a novel collagen scaffold impregnated with antibacterial agent for delivering drug in a controlled manner, thereby reducing the frequency of dressing. The dressing, developed in the form of a scaffold, acts as an osmotic regulator and makes the wound assessment easier by clinicians.
Reconstituted Collagen sponge
A collagenous source is made free from non-collagenous materials to get a pure collagen solution, which is treated with foaming agent, drug solution and cross linking agents followed by lyophilisation and subsequent sterilisation by conventional method to prepare the reconstituted collagen sponge. It has enormous application as wound dressing aid, particularly bleeding and oozing open wounds. It ensures minimum fluid loss from the wound site, thereby enhancing healing rate of wounds, burns etc. The uniqueness of the process lies in the economical utilisation of slaughterhouse byproducts, which are otherwise thrown away, thereby making wealth out of waste. Moreover, the soluble pure collagen solution, produced as an intermediate is used in cosmetic and pharmaceutical industries.
Ionically charged Collagen sponge
The polar sites of collagen are modified using charged ligands under inert atmosphere to prepare ionically charged collagen solution, which is cast into sponge of desired shape and size after incorporating foaming agent, crosslinker and drugs.
The product has enormous application for treating wounds of ionic nature. Thus it finds effective use as corneal shield in ophthalmologic treatment. The porous nature of the product allows faster tissue growth. The soluble collagen solution, obtained as an intermediate, is used in cosmetic and pharmaceutical industries.
A novel wound dressing material ( Aminograft)
Amniograft is a cost effective biocompatible wound dressing material, which is repared by chemically modifying the human amniotic membrane by using suitable crosslinker and subsequently drying the resulting product followed by sterilisation. The product, identified as Amniograft, has enormous application for the purpose of management of wounds of various nature. Since it is a homograft while using for human wound dressing, the compatibility of the product is much more compared to that of the conventional materials, which are usually made from the bovine source.
Haemostatic wound healing powder
It is a cost effective, biocompatible as well as biodegradable chemically modified fibrin powder, which is prepared by graft copolymerising purified, bleached and masticated fibrin with an acrylic monomer, followed by optional incorporation of drug and subsequent drying and pulverising. The powder has potential use as a dressing aid in the treatment of various wounds of diversified nature including external injury, cut, burn and even ulcers in animal as well as human being. It prevents loss of electrolyte from the wound site and also prevents any infection in the wound. The uniqueness of the process lies in the economical utlisation of crude fibrin, which is otherwise thrown as waste, thereby making wealth out of waste.
Haemostatic fibrin sponge
It is a cost effective, biocompatible as well as biodegradable hemostats, which is prepared by subjecting the pure fibrin paste, obtained by masticating purified, bleached fibrin with optional treatment with crosslinkers, to freezing, lyophilisation followed by sterilisation. The sponge has potential use as a dressing aid in the treatment of various wounds of diversified nature including external injury, cut, burn and even ulcers in animal as well as human being. It may also be used for surgical applications. It prevents loss of electrolyte from the wound site, absorbs any blood/serum oozing out of the wound and also prevents any infection in the wound.
The uniqueness of the process lies in the economical utlisation of crude fibrin, which is otherwise thrown as waste, thereby making wealth out of waste.
Haemostatic wound healing sheet
It is a cost effective, biocompatible as well as biodegradable chemically modified fibrin sheet which is prepared by graft copolymerising the fibrin film, obtained by drying the purified, bleached and masticated fibrin paste, with a biocompatible, hydrophilic monomer, followed by optional incorporation of drug and subsequent drying and casting into sheet of desired size and shape. The sheet has potential use as a dressing aid in the treatment of various wounds of diversified nature including external injury, cut, burn and even ulcers in animal as well as human being. It prevents loss of electrolyte from the wound site and also prevents any infection in the wound. The uniqueness of the process lies in the economical utlisation of crude fibrin, which is otherwise thrown as waste, thereby making wealth out of waste.
Haemostatic wound dressing material ( Haem Gel Band)
A cost effective, biocompatible haemostatic wound dressing material in the form of powder/sheet, which is prepared from gelatin and a bio-compatible polymer by graft copolymerisation. It has enormous use in the dressing of any kind of wound including those of stab wound, leprosy, diabetic ulcer etc.
Fibrogel - A wound dressing material
This wound dressing material essentially contains fibrin and gelatin. The product is biocompatible and exhibits haemostatic property. ELISA test has confirmed that wound healing rate is enhanced with no adverse immunological reactions. The product has been found to be a very effective wound dressing material on the clinical wounds of smaller and bigger animals at different Veterinary Colleges. It has a good potential as wound dressing aid in human.
Polyacrylate dispersion for sustained drug release
A mixture of acrylate ester monomers is subjected to polymerization by delayed addition technique. Free monomer content of the dispersion is less than 0.1%v/v. The polyacrylate dispersion finds potential application in pharmaceutical industry. The technology is patent protected and has been commercialized.